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NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required)

National Institutes of Health

Opportunity Number PAR-27-065
Status posted
Opens 08/31/2026
Deadline 03/09/2029

About This Opportunity

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.

Eligibility

Others (see text field entitled "Additional Information on Eligibility" for clarification) County governments Public and State controlled institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities

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